FNDC5/irisin ameliorates diabetes-associated cognitive dysfunction via αVβ5-cAMP signaling to regulate oxidative stress, neuroinflammation and synaptic plasticity.

J Transl Med · 2026 · PMC13151342 · PMID 41904576

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did not reach statistical significanceno p-value reported

ELISA analysis revealed a downward trend in serum Irisin levels in DM rats; however, the differences compared with CON did not reach statistical significance at any time point (Fig. 1 K).

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