Metabolic features in plasma and urine of obese children and their association with MAFLD risk.

This discrepancy may be attributed to: (i) control group specificity: obese children without MAFLD may already exhibit altered metabolite levels seen in simple obesity; (ii) disease severity: early-stage MAFLD may not yet show dysregulation of markers associated with advanced disease; (iii) platform limitations: targeted metabolomics did not cover all lipid peroxidation products; and (iv) statistical stringency: FDR correction may have excluded nominally significant metabolites.

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