Mapping HLA class I and II allele associations with hepatitis C related liver disease progression in an Egyptian cohort.

Discov Oncol · 2026 · PMC13153355 · PMID 42095996

Europe PMC DOI

hedged sentences

0.0540

closest p · 1.1× alpha

0.0540

boldest claim

The sentences

approached but did not reach significanceP = 0.054so close (0.05 < p ≤ 0.1)

While HLA - C*06 frequencies across groups approached but did not reach significance ( P = 0.054; P adj =0.594), its reduced presence in LC cases suggests a possible protective effect against fibrosis progression in HCV, consistent with reports implicating it in resistance to portal fibrosis [ 33 ].

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borderline significanceno p-value reported

Comparative analysis across the four clinical groups revealed associations with borderline significance after adjustment, alongside nominal trends.

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did not reach statistical significanceno p-value reported

Several alleles showed frequency differences that did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.