Hypothalamic-superior frontal gyrus functional connectivity alterations and luteinizing hormone correlations in girls with central precocious puberty.

Ann Pediatr Endocrinol Metab · 2026 · PMC13153794 · PMID 42099116

Europe PMC DOI

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closest p · 1.0× alpha

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showed a trendP =0.050actually significant

In CPP patients, FC between the right lateral hypothalamus and right SFG showed a trend-level correlation with peak LH levels (r=0.362, P =0.050).

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borderline significantno p-value reported

Patients with CPP exhibited enhanced neural synchronization linking the right lateral hypothalamic effector zone to the right superior frontal gyrus (displaying a borderline significant correlation with peak LH concentrations), concurrent with diminished functional coupling of the right lateral hypothalamic efferent to the right fusiform/supramarginal gyri.

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