Transcriptomic and phenotypic convergence of neurodevelopmental disorder risk genes in vitro and in vivo.

The transcriptomic effects of individual NDD genes cluster by cell type: the strongest NDD gene correlations are in mature iGLUTs; that is, all nominally significant ( P < 0.01) log 2 fold change (FC) DEGs are most highly correlated with each other and least correlated with the other cell types, whether relative to all scramble control cells (Fig. 1e(i),(ii) and Supplementary Fig. 7c(ii) ) or to random subsets of scramble control cells (Supplementary Fig. 8a,b ).

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