Effective Doses and Predictors of Dexmedetomidine for Inducing Specific Sleep Stages (N2/N3) in Chronic Insomnia: A Retrospective Cohort Study.

Nat Sci Sleep · 2026 · PMC13157349 · PMID 42117080

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did not reach statistical significanceno p-value reported

However, the test for nonlinearity did not reach statistical significance (P-nonlinear = 0.365), suggesting that within the observed BMI range of this cohort, a linear approximation of this relationship may be statistically acceptable, despite the visual suggestion of a potential threshold or inflection point around 22 kg/m 2 .

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an increasing trendno p-value reported

The fitted curve ( Figure 4b ) showed a relatively flat relationship for BMI values between approximately 21 and 25 kg/m 2 , with a suggestion of an increasing trend in the required Dex-N3 dose at BMI values above 25 kg/m 2 .

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