A tissue-intrinsic mechanism sensitizes HIV-1 particles for TLR-triggered innate immune responses.

On both, CD4 + T cells and MDMs, productive infection by particles with prior contact to DC was significantly reduced (3.6-fold reduction to 27.5% of suspension on CD4 + T cells, 2.9-fold reduction to 34.8% of suspension on MDMs) and LC only mediated a very mild reduction that did not reach statistical significance (1.8-fold on CD4 + T cells, 1.4-fold on MDMs).

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