Efficacy and Safety of Escitalopram for Major Depressive Disorder in Children and Adolescents: A Systematic Review and Meta-Analysis with Age-Specific Findings.

Neuropsychiatr Dis Treat · 2026 · PMC13157702 · PMID 42116863

Europe PMC DOI

hedged sentence

0.0510

closest p · 1.0× alpha

0.0510

boldest claim

The sentences

did not reach statistical significancep=0.051so close (0.05 < p ≤ 0.1)

Although the primary endpoint did not reach statistical significance (time to relapse: HR=2.96, 95% CI 0.94–9.30, p=0.051), escitalopram showed a numerical improvement suggesting possible benefit in relapse prevention.

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