Investigating the pathogenic role of calpain proteases and the therapeutic potential of their inhibition in mice modelling Machado-Joseph disease.

Hum Mol Genet · 2026 · PMC13158246 · PMID 41493127

Europe PMC DOI

hedged sentence

0.0815

closest p · 1.6× alpha

0.0815

boldest claim

The sentences

did not reach statistical significanceP = 0.0815so close (0.05 < p ≤ 0.1)

Densiometric analysis of 145-150 kDa cleaved αII-spectrin (150 and 145 kDa fragments) normalised to GAPDH suggested a trend towards increased αII-spectrin in MJD animals; however, this did not reach statistical significance ( P = 0.0815, Fig. 3E ).

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.