Obesity-driven phosphatidylethanolamine dysregulation impairs neuroimmune crosstalk and accelerates Alzheimer's pathogenesis.

Proteomic profiling of EV-treated brains showed that HFD-EVs triggered widespread protein deregulation, which showed a trend of enrichment of several pathways at nominal level with p < 0.05, including activation of lipid catabolism, neurodegeneration-related pathways (e.g., Alzheimer’s and Parkinson’s disease), mitochondrial pathways, acetylation pathways, and insulin secretion regulation (Fig. 3 H; Tables S2 – S3 ).

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