Characterisation of tumor-infiltrating gamma-delta T cells in human colorectal cancer with MHC-I loss.

14 The comparison of MHC‐I expression between dMMR and pMMR subgroups revealed a trend toward increased MHC‐I − loss in dMMR tumors for both all‐stage (28% vs 42%, respectively) and stage III (31% vs 40%, respectively) analysis, though this did not reach statistical significance (Figure 3d ).

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Further stratification by MMR status revealed that this increase in stromal γδ T cells ( P < 0.001) and PD‐1 expression ( P < 0.01) was highly significant in pMMR CRCs with MHC‐I loss but not in dMMR CRCs (Figure 4e , Supplementary figure 1F ).

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