Cytoskeletal Imbalance and Axonal Vulnerability in Sporadic PSP-RS: Early Changes in a Human iPSC-Derived Neuronal Model with Altered mTOR Signaling.

Immunoblot analysis of NEFL revealed a temporal pattern of axonal dysfunction, with significant increases in PSP-RS neurons at DIV 45 and 60 compared to controls ( Figure 4 D,E), whereas analysis of NEFH at Day 60 showed a trend toward increased levels in PSP-RS neurons, though not reaching statistical significance ( Figure 4 F,G).

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