Carbon and Nitrogen Isotopic Signatures as Metabolic Biomarkers of Nodal Metastasis and Recurrence in Oral Squamous Cell Carcinoma.

Cancers (Basel) · 2026 · PMC13162935 · PMID 42122257

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

0.4200

boldest claim

The sentences

a nonsignificant trendp = 0.07so close (0.05 < p ≤ 0.1)

Interestingly, δ 13 C measured in tumor tissue showed only a nonsignificant trend toward shorter DFS (HR 1.44, 95% CI 0.97–2.14, p = 0.07), while δ 13 C tumor–margin differences were not associated with DFS.

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did not reach statistical significancep = 0.42not close (p > 0.1)

Kaplan–Meier analysis of DFS was performed using a median-based cut-off separation of survival curves; however, the difference did not reach statistical significance ( Figure 3 , log-rank p = 0.42).

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