Within the 3,5-dihalogenated series ( 52 – 54 ), a clear trend emerged, di-F (inactive) < di-Cl (26–33 μM) < di-Br (13–17 μM), consistent with the increasing size and polarizability of the halogens, which can enhance hydrophobic contacts and potentially halogen bonding.
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Coumarin-Thiourea Hybrids: Structural Features Governing CA Inhibition and Antiproliferative Effects.
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