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Pirfenidone Suppresses Liver Fibrosis Through Inhibition of TGF-β-Associated Lipid Metabolic Remodeling in Hepatic Stellate Cells.

Int J Mol Sci · 2026 · PMC13164092 · PMID 42123641

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In both cell lines, TGF-β1 significantly increased intracellular neutral lipid fluorescence, whereas TGF-β2 showed a similar trend that did not reach statistical significance under the tested conditions ( Figure 3 A,B).

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