Differential Roles of IL-18 and IL-8 Gene Variations in Multiple Sclerosis: Associations with Susceptibility and MRI Disease Activity.

J Clin Med · 2026 · PMC13164207 · PMID 42123012

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hedged sentences

0.0009

closest p · 0.0× alpha

0.0009

boldest claim

The sentences

highly significantp = 0.0009actually significant

The distribution of IL-18 (−137 G/C) genotypes showed a highly significant difference between MS patients and controls ( p = 0.0009), derived from a comprehensive genotype-based comparison (AA vs.

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did not reach statistical significanceno p-value reported

Similarly, patients with the IL-8 (−251 AA genotype) tended to have slightly higher EDSS scores, although this difference did not reach statistical significance.

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