Barely Significant
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Mid-Term Oncological Outcomes of Vaginal Natural Orifice Transluminal Endoscopic Surgery Compared with Total Laparoscopic Hysterectomy for Early-Stage Endometrial Cancer: A Single-Center Retrospective Study.

J Clin Med · 2026 · PMC13164299 · PMID 42123082

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Baseline demographic characteristics were broadly similar between the two groups; however, postoperative adjuvant therapy was more frequent in the vNOTES group, and pathological upstaging was numerically more frequent in the vNOTES group, although the difference did not reach statistical significance.

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a nonsignificant trendno p-value reported
On multivariable Cox proportional hazards regression analysis, lymphovascular space invasion was the only significant prognostic factor for RFS, whereas pathological upstaging showed a nonsignificant trend ( Table 3 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.