Barely Significant
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Melatonin Supplementation and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis of Randomized Trials.

J Clin Med · 2026 · PMC13164420 · PMID 42123177

Europe PMCDOI
1
hedged sentence
0.0800
closest p · 1.6× alpha
0.0800
boldest claim

The sentences

did not reach statistical significancep = 0.08so close (0.05 < p ≤ 0.1)
Final LVEF and Change in LVEF from Baseline to Follow-Up Across all available randomized controlled trials, pooled analysis of final left ventricular ejection fraction (LVEF) showed that melatonin was associated with a numerically higher final LVEF than control, although the overall difference did not reach statistical significance (mean difference, 2.24 percentage points; 95% CI, −0.31 to 4.80; p = 0.08) ( Figure 1 ).

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