Machine Learning-Driven QSAR Modeling for pK<sub>a</sub> Prediction of Ionizable Lipids in Lipid Nanoparticles for Hepatic Gene Silencing.

Int J Mol Sci · 2026 · PMC13164459 · PMID 42123652

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a negative trendno p-value reported

The BIC descriptor exhibits a negative trend with increasing SHAP values ( Figure 5 b).

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Machine Learning-Driven QSAR Modeling for pK&lt;sub&gt;a&lt;/sub&gt; Prediction of Ionizable Lipids in Lipid Nanoparticles for Hepatic Gene Silencing.

The sentences

Machine Learning-Driven QSAR Modeling for pK<sub>a</sub> Prediction of Ionizable Lipids in Lipid Nanoparticles for Hepatic Gene Silencing.