Clinical Implications of p16 Evaluation in a Purposively Sampled Cohort of High-Risk Breast Cancer Phenotypes.

Int J Mol Sci · 2026 · PMC13164544 · PMID 42123675

Europe PMC DOI

hedged sentence

0.0750

closest p · 1.5× alpha

0.0750

boldest claim

The sentences

did not reach statistical significancep = 0.075so close (0.05 < p ≤ 0.1)

A trend towards elevated p16 expression was observed in ductal carcinomas (89.7% of high expressors) compared to lobular subtypes (7.4% of high expressors), although this difference approached but did not reach statistical significance ( p = 0.075; Cramer’s V = 0.228).

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