Analysis of BA species in cecal homogenates revealed an interaction between microbial status and fat ( p = 0.026) for DCA ( Figure 5D ), where HFVHC-fed SPF mice exhibited significantly increased levels relative to all groups except for HF, although a numerical trend was evident.
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Gut microbes mediate the synergistic effects of dietary cholesterol and saturated fat in driving fibrosing MASH.
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LFVHC- and HFVHC-fed mice exhibited numerically elevated expression of Cyp7a1 at 8 weeks, although these increases did not reach statistical significance at this timepoint ( Figure 4A ).