Epithelial TMPRSS2 impairs glucose homeostasis in obese mice by regulating ghrelin-GLP-1 receptor signaling pathway.

When compared with PAR2-WT mice, fasted PAR2-G37I mice showed a trend toward reduced GIP secretion, whereas both male and female fasted PAR2-R38E mice showed significantly reduced GIP levels ( Figure 1E ) without alterations in GLP-1 levels ( Figure 1F ).

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