First-line therapies for unresectable hepatocellular carcinoma: a network meta-analysis of immune checkpoint inhibitors and transarterial therapies based on 35 randomized trials.

Front Oncol · 2026 · PMC13167520 · PMID 42137150

Europe PMC DOI

hedged sentences

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closest p

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boldest claim

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did not reach statistical significanceno p-value reported

For example, while DEB-TACE-Apa achieved the highest SUCRA ranking for OS (82.7%) in our analysis, its direct comparison with Sora exhibited a wide credible interval and moderate-quality evidence and, importantly, did not reach statistical significance.

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highly significantno p-value reported

Regarding ORR, HAIC monotherapy exhibited a highly significant efficacy, notably superior to Sora and other regimens, and was underpinned by high-quality evidence.

also in 132,142 other papers

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