Ancestry-informative markers and variants of uncertain significance on hereditary cancer panels.

Front Oncol · 2026 · PMC13167527 · PMID 42137137

Europe PMC DOI

hedged sentences

0.2180

closest p · 4.4× alpha

0.2180

boldest claim

The sentences

did not reach statistical significancep = 0.218not close (p > 0.1)

Non-Hispanic Black participants had an elevated odds ratio comparable to the Asian cohort, but this did not reach statistical significance (OR = 2.08, 95% CI: 0.67–7.24, p = 0.218).

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a positive trendno p-value reported

Furthermore, in an exploratory secondary analysis modeling genetic similarity continuously, we observed a positive trend between Indigenous American ancestry and VUS odds within the Hispanic cohort.

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