Sleep and circadian disruption reshape immune homeostasis in oral tissues: mechanistic roles of melatonin and cortisol in periodontal disease and xerostomia.

A 2021 cohort study of 30 OSA patients found that 73.3% reported xerostomia, and 20% had objectively measured hyposalivation, with a clear trend of worse symptoms in moderate to severe OSA (salivary flow: 0.28 mL/min mild vs 0.14 mL/min severe; p < 0.05) ( 67 ).

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