Single cell transcriptomic analysis reveals pathogenic cell heterogeneity and candidate inflammatory-associated markers in STZ-induced diabetic mouse retina.

Front Immunol · 2026 · PMC13168181 · PMID 42136644

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Notably, under STZ conditions, Module 1 showed a trend toward increased activity in Cluster 0, and Module 6 was similarly elevated in Cluster 1, indicating that these two modules are preferentially activated within distinct Müller substates during STZ-induced DR and may contribute to STZ-associated remodeling.

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