Age at onset of Parkinson's disease modulates the sphingolipid-dopaminergic interplay in autonomic progression.

NPJ Parkinsons Dis · 2026 · PMC13168328 · PMID 41857040

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hedged sentence

0.0770

closest p · 1.5× alpha

0.0770

boldest claim

The sentences

showed a trendp = 0.077so close (0.05 < p ≤ 0.1)

Interaction analyses further revealed that in EOPD, the interaction between C16 GlcCer and left caudate SBR was associated with a substantially elevated hazard (HR = 6119.852, p = 0.004), whereas the interaction between C16 GlcCer and left anterior putamen SBR also showed a trend toward increased risk (HR = 936.206, p = 0.077).

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