African ancestry-enriched variants in the GATM gene are associated with elevated serum creatinine levels.

However, the three nominally significant variants in the credible set (rs10767873, rs3925584, and rs963837) have previously been associated with kidney-related functions via GWAS in numerous ancestrally diverse cohorts, including Scr levels, glomerular filtration rate, and kidney disease [ 36 – 53 ].

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We found a highly significant association between Scr levels and African ancestry-enriched variants at chromosome 15 (15q23:45.3 Mb-45.5 Mb), which replicates across three different association methods (Fig. 2 ).

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