PPT1 selectively depalmitoylates GAP43 to regulate neuronal excitability and cognitive function.

Sci Adv · 2026 · PMC13170661 · PMID 42127180

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showed a trendno p-value reported

We also note that in PPT1-KO mice, GAP43 hyperpalmitoylation was most pronounced at 1 to 3 months and showed a trend of decrease at 6 months ( Fig. 1, H and I ).

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