Enhanced anti-hyperuricemic effect of Simiao pill by composite lactic acid bacteria fermentation: ferulic acid and berberine enrichment and URAT1/OAT1/XOD regulation.

Front Pharmacol · 2026 · PMC13171833 · PMID 42147310

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a decreasing trendno p-value reported

As shown in Figure 4B , during the modeling period, the body weight of mice in all groups exhibited a decreasing trend, with the exception of the NC group.

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showed a trendno p-value reported

Compared to the HUA and SP groups, the FSP-H group significantly reduced UA and BUN levels (P < 0.0001, P < 0.001) and showed a trend toward restoring XOD levels to normal.

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highly significantno p-value reported

The P-value <0.0001 indicates that the quadratic multivariate regression model is highly significant, with an F-value of 150.30.

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