Integrative analysis identifies DCBLD2 and immune-related biomarkers for major depressive disorder: evidence from human peripheral blood, post-mortem brain, and rat models.

Front Hum Neurosci · 2026 · PMC13171845 · PMID 42148317

Europe PMC DOI

hedged sentences

0.0760

closest p · 1.5× alpha

0.0760

boldest claim

The sentences

marginally significantp = 0.076so close (0.05 < p ≤ 0.1)

In our multivariate regression analysis, RNF144B expression showed a marginally significant negative association with MDD ( p = 0.076), suggesting its downregulation may be related to the disease.

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did not reach statistical significanceno p-value reported

Although the expression changes of FZD5 and RNF144B in GSE53987 did not reach statistical significance, we nonetheless examined them in the rat prefrontal cortex.

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