Antigen-specific immunotherapy with a CD4<sup>+</sup> T cell neoepitope restrains CD8<sup>+</sup> T cell differentiation in murine pancreatic islet grafts.

Nat Commun · 2026 · PMC13171880 · PMID 41872174

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near-significantno p-value reported

Upon graft failure, there was a near-significant increase of IGRP CD8 T cells in the islet graft compared to d15 (Fig. 7d ); this was also the case for IGRP tetramer-negative CD8 T cells (Fig.

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Antigen-specific immunotherapy with a CD4&lt;sup&gt;+&lt;/sup&gt; T cell neoepitope restrains CD8&lt;sup&gt;+&lt;/sup&gt; T cell differentiation in murine pancreatic islet grafts.

The sentences

Antigen-specific immunotherapy with a CD4<sup>+</sup> T cell neoepitope restrains CD8<sup>+</sup> T cell differentiation in murine pancreatic islet grafts.