Exploring the Association of Genetic Determinants of SIRT1, MTHFR, and MIR146A Gene Polymorphism with the Ischemic Stroke Predisposition: A Case Control Study.

Cell Mol Neurobiol · 2026 · PMC13172177 · PMID 41957297

Europe PMC DOI

hedged sentences

0.0004

closest p · 0.0× alpha

0.0650

boldest claim

The sentences

highly significantP = 0.0004actually significant

AA) further supported this finding, showing a highly significant risk elevation (OR = 2.85, P = 0.0004), and the MTHFR C allele itself exhibited the strongest allelic association observed (OR = 2.17, P = 0.0004).

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did not reach statistical significanceP = 0.065so close (0.05 < p ≤ 0.1)

In the recessive model, MIR146A CC and MTHFR CC genotypes were significantly associated with stroke risk, whereas the SIRT1 CC genotype did not reach statistical significance ( P = 0.065).

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