Ecological and Functional Stratification of the Stool Microbiome Predicts Response to Immune Checkpoint Inhibitors across Cancer Types.

Comput Struct Biotechnol J · 2026 · PMC13173278 · PMID 42146906

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.1900

boldest claim

The sentences

highly significantP < 2.0e−16actually significant

In parallel, a linear model assessing the direct association between mean relative abundance and response demonstrated a highly significant positive effect (estimate = 0.30, P < 2.0e−16), with dataset terms again showing no significant influence (all P > 0.05), underscoring the robustness of abundance-based signals across cohorts.

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did not reach statistical significanceP = 0.19not close (p > 0.1)

The Proteobacteria relative abundance achieved a mean ROC AUC of 0.63 ± 0.11, a difference that did not reach statistical significance (Wilcoxon rank-sum test, P = 0.19).

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