Chestnut-derived ellagitannins (FT50) protect against western diet-induced metabolic dysfunction and preserve beta cell function in mice.

At week 12, this effect was more pronounced, with a highly significant reduction in fasting insulin (**p < 0.01) in the WD+FT50 group ( Figure 4D ).

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After 12 weeks, plasma triglyceride levels showed a tendency to decrease in the FT50 group compared to WD alone, although this difference did not reach statistical significance (p decreased from 0.9044 at baseline to 0.1954 at week 12; Figure 1B ).

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