Additionally, succinate dilution (M4 succinate to M5 glutamate) showed a trend of being lower in the ICM than in TE, and in the EC compared with the EPI, which is consistent with the reduced contribution of unlabeled sources in these lineages ( Figure S2 E), mirroring the lactate labeling experiment.
← all excerpts
TCA cycle rewiring underpins histone acetylation sourcing and cell-fate transitions during exit from naive pluripotency.
1
—
—