Circulating Inflammatory Proteins and Fuchs Endothelial Corneal Dystrophy: A Mendelian Randomization and Bioinformatics-Based Investigation.

Transl Vis Sci Technol · 2026 · PMC13175216 · PMID 42101419

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closest p

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did not reach statistical significanceno p-value reported

MIP-1β levels exhibited a consistent protective trend across all three cohorts, although its meta-analysis P value did not reach statistical significance (OR = 0.919; 95% CI, 0.840–1.006; P _meta = 0.06749).

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failed to reach significanceno p-value reported

Regarding MIP-1β, despite a consistent protective trend, the association failed to reach significance in the meta-analysis, and our power calculation indicated that the analysis was underpowered to detect small effect sizes reliably.

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