Transcriptomic profiling reveals substrate- and shear stress-dependent maturation of human small intestinal epithelial cells.

Front Pharmacol · 2026 · PMC13175875 · PMID 42147349

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showed a trendno p-value reported

Overall, ISC-derived monolayers on dSIS-MA hydrogels showed a trend toward absorptive lineage maturation with reduced secretory and crypt-based signatures, though some discrepancies between RNA-seq and RT-qPCR warrant cautious interpretation.

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