Systemic inflammatory response index is associated with increased all-cause and cardiovascular mortality in obstructive sleep apnea: evidence from NHANES and validation with an external hospital-based dataset.

Although the intermediate quartiles (Q2 and Q3) did not reach statistical significance, a clear dose–response pattern was evident, with significant trends across quartiles confirmed in all models ( p for trend = 0.012 in Model A, 0.014 in Model B, and 0.013 in Model C).

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Introduction Obstructive sleep apnea (OSA) is a highly concerning sleep disorder, and its prevalence has shown an increasing trend year by year ( 1 ).

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