Fc-mediated antibody functions are associated with disease severity in COVID-19.

Front Immunol · 2026 · PMC13176313 · PMID 42148134

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did not reach statistical significanceno p-value reported

For example, against the Wuhan-hu-1 spike, the median FcγRIIa-mediated reporter activity was 1.51 (IQR 1.02–2.16) in patients with mild disease versus 2.44 (IQR 1.24–4.70) in those with severe disease ( p = 0.066), although this difference did not reach statistical significance.

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