Ontogeny of Placental FcRn Protein During Human and Animal Pregnancy to Inform Developmental Toxicity Testing.

Birth Defects Res · 2026 · PMC13176392 · PMID 42135602

Europe PMC DOI

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a clear trendno p-value reported

For FcRn concentration in the InvYSP in the guinea pig there was a clear trend of increasing concentration, 8.6×, 24×, 62×, 40× on GD 21, 30, 45 and 60, respectively compared with GD 15.

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a slight trendno p-value reported

For the rabbit CAP concentrations, there were very slight variations at all measured timepoints, with a slight trend for increasing as gestation progressed; concentrations were 0.67×, 1.1×, 1.9×, 2.3×, and 2.0× of GD 10 level on GD 13, 16, 19, 24, and 29, respectively.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.