nominally significantp < 0.0001
Of note, each comparison of atropine sulfate 0.01% versus vehicle and atropine sulfate 0.03% versus vehicle was nominally significant ( p < 0.0001 and p = 0.0023, respectively) (Fig. 3 ). s In Fast Progressor Subgroup 2 (progression − 0.75 D/year or worse at baseline, n = 225), the mean (least squares means) APR from baseline to month 24 was − 0.53 D (95% CI − 0.63, − 0.43) in the vehicle group and − 0.38 D (95% CI − 0.47, − 0.30) in the combined atropine sulfate group.