Impact of Frailty (Clinical Frailty Scale) on Weaning from Mechanical Ventilation: A Systematic Review and Meta-analysis.

Although advancing age is associated with declining physiological resilience, age-stratified subgroup analyses did not reach statistical significance, suggesting that the prognostic association of frailty with weaning outcomes may not be confined to older patients alone. 43 Similarly, there was no statistically significant difference across subgroups representing early and late weaning failure, indicating that frailty may remain a relevant prognostic marker throughout the weaning process.

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