Neuronal loss of the pentose phosphate pathway in the living nervous system is causally linked to [NADPH] reduction and elevated oxidative stress.

In doing so, we see a significant reduction in cellular NADPH levels for Pgd knockdown, but not G6Pdh knockdown, albeit there is a clear trend here as well (Fig. 4 ; note: if the fluorescence values drop lower upon CHP application and recover less upon NADPH application in respect to the baseline, the ratio is greater.

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