Microvascular endothelial scavenger receptor class B type I protects against heart failure with preserved ejection fraction by inhibiting T-cell cardiotropism.

EMBO Mol Med · 2026 · PMC13179366 · PMID 41975084

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did not reach statistical significanceno p-value reported

Notably, compared to S fl/fl HFpEF mice, S ΔEC HFpEF mice exhibited a consistent trend toward more severe cardiac hypertrophy (as evidenced by LV mass and left ventricular remodeling index (LVRI) parameters) and worse diastolic dysfunction (indicated by myocardial performance index (MPI) and E/e’ ratio), but these differences did not reach statistical significance.

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