HLA-B*44 Alleles and HLA-DQA1*03:01 as Genetic Risk Factors for Drug-Induced Liver Injury due to Fluoroquinolones.

While our finding of an increased incidence of DQA1*03:01 in the cases (OR 2.81 [1.36–5.81], p = 0.005) is very similar to the findings reported for this class II allele in the previous study, we obtained no evidence for a significant alteration in HLA‐B*57:01 frequency among our cases and instead see a highly significant increase in frequency of the HLA‐B*44 family (5.33 [2.45–11.61], 2.5 × 10 −5 ), including a strong association with the B*44:03 allele (6.01 [2.37–15.28], p = 0.0002).

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In addition to the B*44 association, we found a borderline significant risk for B*45:01 as a risk factor in two additional cases.

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Table S7: Summary statistics of the nominally significant HLA allele in the ciprofloxacin‐restricted analysis, along with other relevant alleles mentioned in the FQ‐DILI analysis.

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