highly significantP < 0.001
Highly significant time and group × time interaction effects were observed for SSS ( F = 38.340 and 29.187, respectively; both P < 0.001).
Highly significant time and group × time interaction effects were observed for SSS ( F = 38.340 and 29.187, respectively; both P < 0.001).
Marginally significant interactions were noted for WPI ( F = 2.886, P = 0.075) and FSS ( F = 2.556, P = 0.099).
At Week 4, the SHG group showed a greater reduction in VAS compared with placebo (mean difference: 1.44 ± 0.95), but this difference did not reach statistical significance ( P = 0.141), although the magnitude exceeded the MCID threshold.