Investigate the heterogeneity of colorectal cancer patients at the single-cell level prior to and subsequent to immunotherapy.

Front Immunol · 2026 · PMC13180829 · PMID 42158872

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an increasing trendno p-value reported

Compared with pre-treatment samples, CXCL13 expression showed an increasing trend after ICB therapy, suggesting a potential association with treatment response.

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did not reach statistical significanceno p-value reported

Kaplan-Meier analysis showed that higher TXNIP expression was significantly associated with improved disease-free survival, whereas HSPA1B exhibited a trend toward poorer survival outcomes, although this did not reach statistical significance ( Supplementary Figures 2A, B ).

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