Effects of low-dose lithium supplementation on thermal inactivation of SERCA in cardiac muscle of male mice.

A decreasing trend in Hsp70 content was seen with heat stress (non-heated Ctrl 0.112 ± 0.017 vs. heated Ctrl 0.101 ± 0.017 and non-heated LiCl 0.116 ± 0.013 vs. heated LiCl 0.091 ± 0.007, main effect of heat stress P = 0.0579; Figure 4 A,B).

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Conversely, lithium treatment increased Ser9 phosphorylation of GSK3, both absolute and relative to total GSK3β protein, though this did not reach statistical significance ( Figure 1 C,D).

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