Safety and efficacy profile of S-005151 (Redasemtide), in patients with chronic liver diseases: phase 2 trial.

A decreasing trend in IgG and an increasing trend in Plt were also observed (Supplementary Fig.

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First, the evaluation of liver injury showed a decreasing trend in AST and ALT levels (Supplementary Fig.

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Regarding fibrosis, the platelet serum markers P-III-P, type IV collagen-7S, hyaluronic acid, M2BPGi, ATX, FIB-4, APRI, MRE, and Sirius Red staining on liver biopsy to assess the fibrotic area and score fibrosis showed an overall trend toward improvement, and there was a tendency for many of these items to move in tandem within individual cases.

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Regarding liver fibrosis, there was a rapid and stable decrease in serum type IV collagen 7S levels, improvement in MR elastography findings, and an increase in platelet counts in some cases; 5 of 10 patients showed a trend toward improvement in liver fibrosis.

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